LDL (“bad”) cholesterol, most strongly linked to atherosclerotic risk.
What it is
LDL cholesterol in mmol/L, often calculated (Friedewald or variants). Calculation is less reliable when triglycerides are very high.
LDL cholesterol is calculated or measured directly; calculation fails when triglycerides are very high. It remains a primary treatment target in many UK CVD pathways.
Why it matters
LDL targets depend on your personal risk category and treatment plan (primary vs secondary prevention). Discuss medicines and diet with a clinician, do not self-start high-dose supplements as a statin substitute.
This guide is educational only and cannot diagnose you. Discuss results, especially anything outside your laboratory’s reference interval, or that does not match how you feel, with a GP or other appropriately qualified clinician.
How it affects the body
LDL particles deliver cholesterol to tissues; retention in artery walls underpins plaque formation over years.
LDL particles deliver cholesterol to tissues via LDL receptors. Hepatic receptor activity (genetics, thyroid status, medicines) strongly influences blood LDL-C.
For athletes
Strength and endurance athletes can still have high LDL from genetics or diet. Fasting status and recent alcohol affect triglycerides and thus calculated LDL.
Lean athletes with familial hypercholesterolaemia still need medical lipid care: fitness is not a cure. Disclose anabolic steroid use; it can wreck lipid profiles.
